Name:  Peter Fenn, BSc, PhD.

Job Title:  Principal

Summary

Provides consulting services in the areas of Integrated Drug Development Programmes and Drug Metabolism. Areas of experience and expertise include:

Non-Clinical Development Strategies

Lead candidate pharmacokinetic optimisation

Advice on in vitro and in vivo metabolism study design

Strategies for early pharmacokinetic development

Regulatory drug metabolism

Non clinical program management

Professional Experience

Education

1983; B.Sc., Reading University
1988; PhD, University of New England (Australia)

Drug Development Experience

Design, conduct and management of drug metabolism studies for screening, discovery and development

Preclinical drug development – strategic planning and program execution

Pharmacokinetic and toxicokinetic data analysis and interpretation

In vitro P450 methodologies and drug-drug interaction studies

Drug Metabolism process in lead optimization

In vitro and in vivo metabolite profiling and biotransformation

Experience in surgical animal models (rodents, dog and monkey) for kinetics, absorption and first-pass effects

Selected Publications

Fenn P.D., Young C.G. and Johnston A.M. (1993) - The use of dual labelling with 125I and 131I for the kinetic evaluation of macromolecules.

Fenn P.D., Cameron B.D. and Donnell D. (1993) - Study of the disposition of a radiolabelled compound following administration as an aerosol to dogs.

Fenn P.D. and Cameron B.D. (1994) - The GLP validation of phosphor imaging analysis for ADME studies. Presented at the Society of Toxicologic Pathologists, 13th International Symposium. Jun 05 09, 1994

Cameron B.D., Johnston A.M., Fenn P.D. and Young C.G. (1994) - The validation and use of phosphor imaging analysis in ADME studies. In: Proceedings of the Sixth North American ISSX Meeting, Raleigh, North Carolina, USA. October 23-27, 1994 ; 155

Cameron B.D., Fenn P.D. and Johnston A.M. (1995) - A comparison of results obtained from conventional tissue distribution and quantitative whole body autoradiography studies. In: Proceedings of the Fourth International ISSX Meeting, Seattle, Washington, USA. August 27-31, 1995; 408

van Wijk H., Fenn P., Jones M. and Weir E. (2001) - Validation of a chronic portal vein cannulation model in the rat. In Animal Technology and Welfare, December 2002, vol 1:157-158

Abernethy L., Dilworth C., Fenn P. and Murray G. (2002) - Validation of commercially supplied cryopreserved hepatocytes for use in metabolic profiling studies. In: Proceedings of the 11th North American ISSX Meeting, Orlando, Florida, USA. October 27-31; 371

Dilworth C., Abernethy L. and Fenn P (2003) - Mechanism based inhibition of Cytochrome P450 in vitro: Implications for drug-drug Interactions. In Proceedings of the 12th North American ISSX Meeting. Providence, Rhode Island, October 12-16

Professional Activities